Sialylated products

What is sialylation?
Sialylation is a process of attaching sialic acid onto molecules, such as oligosaccharides and carbohydrates, as the terminal monosaccharide.
Sialyllactose, the best gift from nature.
Sialyllactose is one of the key nutrients that mothers give to babies for the first time.
There are two types of Sialyllactoses; 3’-sialyllactose and 6’-sialyllactose. Sialyllactose in breast milk supports various physiological activities such as brain & cognitive development 1), boosting immune system 2), infection prevention 3), etc. GeneChem is the only company in the world, capable to produce large-scale of sialyllactose through sialylation technology rather than extraction or chemical synthesis.
Siallac3®, GeneChem’s 3’-sialyllactose, received US FDA GRAS status, and Siallac6®, GeneChem’s 6’-sialyllactose, is under review for US FDA GRAS status.
* Siallac3® is the trade name of GeneChem’s 3’-sialyllactose, NOT an extract of human milk.
* Siallac6 ® is the trade name of GeneChem’s 6’-sialyllactose, NOT an extract of human milk.


Sialyl Lewisx
Lewisx, also called CD15, is known to be involved in cell adhesion and migration. Sialyl Lewisx (SLex), attached to the O-glycan on the cell surface, is known to play an important role in the intercellular cognition process.4)
Various sialylated products such as 3’-sialyl-N-acetyllactosamine sodium salt, 6’-sialyl-N-acetyllactosamine sodium salt, and sialyllacto-N-tetraose a (LSTa) sodium salt are also produced.


Reference
  • 1) TTarr AJ, Galley JD, Fisher SE, Chichlowski M, Berg BM, Bailey MT, The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis. Brain, Behavior, and Immunity, 50:166-177
  • 2) Comstock SS, Li M, Wang M, Monaco MH, Kuhlenschmidt TB, Kuhlenschmidt MS, Donovan SM, Dietary Human Milk Oligosaccharides but Not Prebiotic Oligosaccharides Increase Circulating Natural Killer Cell and Mesenteric Lymph Node Memory T Cell Populations in Noninfected and Rotavirus-Infected Neonatal Piglets. The Journal of Nutrition, 147(6):1041-1047.
  • 3) Laucirica DR, Triantis V, Schoemaker R, Estes MK, Ramani S, Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells. The Journal of Nutrition, 147(9):1709-1714
  • 4) Allahverdian, S., Wojcik, K. R., & Dorscheid, D. R. (2006). Airway epithelial wound repair: role of carbohydrate sialyl Lewisx. American Journal of Physiology-Lung Cellular and Molecular Physiology, 291(4), L828-L836.